PERC Epilepsy Surgery Interest Group

The PERC Epilepsy Surgery Interest Group is a network of U.S. pediatric epilepsy centers formed in 2018 to characterize the use of pediatric epilepsy surgery and to investigate evaluation strategies and surgical techniques. The group’s mission is to facilitate collegial, collaborative, practice-changing research that delivers answers needed to improve and define best practices for candidate selection for epilepsy surgery treatment.

Members

  • Jane and John Justin Institute for Mind Health, Neurosciences Center, Cook Children’s Medical Center – M. Scott Perry, M.D.
  • Children’s National Hospital; George Washington University – Madison M. Berl, PhD
  • Children’s Hospital of Colorado; University of Colorado School of Medicine – Allyson L. Alexander, M.D., PhD
  • Medical College of Wisconsin – Rene Andrade-Machado, M.D.
  • UT Southwestern – Dallas Armstrong, M.D.
  • University of California San Francisco – Kurtis Auguste, M.D.
  • Boston Children’s Hospital; Harvard Medical School – Jeffrey Bolton, M.D.
  • University of Iowa Hospitals and Clinics, Department of Psychiatry & Pediatrics – Michael Ciliberto, M.D.
  • Oregon Health and Science University – Jason Coryell, M.D.
  • Children’s National Hospital – Dewi Depositario-Cabacar, M.D.
  • Children’s Hospital of Colorado; University of Colorado School of Medicine – Krista Eschbach, M.D.
  • Children’s National Hospital and George Washington Univeristy – William D. Gaillard, M.D.
  • Children’s Healthcare of Atlanta; Emory University School of Medicine – Satya Gedela, M.D.
  • University of California San Francisco – Ernesto Gonzalez-Giraldo, M.D.
  • Cornell University – Zachary Grinspan, M.D.
  • Seattle Children’s Hospital – Jason Hauptman M.D., PhD
  • Medical College of Wisconsin – Pradeep Javarayee, M.D.
  • Norton Neuroscience Institute – Samir Karia, M.D.
  • Vanderbilt University Medical Center – Chad Mac Manuel, M.D.
  • John Hopkins University – Ahmad Marashly, M.D.
  • Vanderbilt University Medical Center – Michael J. McCormack, M.D.
  • University of Michigan – Nancy McNamara, M.D.
  • Cornell University – Srishti Nangia, M.D.
  • Seattle Children’s Hospital, Department of Neurosciences, University of Washington, Department of Neurology – Edward John Novotny, Jr., M.D.
  • University of California San Francisco – Adam Numis,M.D.
  • Children’s Health of Orange County – Joffre Olaya, M.D.
  • Children’s National Hospital; George Washington University – Chima Oluigbo, M.D.
  • Nationwide Children’s Hospital and The Ohio State University – Adam Ostendorf, M.D.
  • Vanderbilt University Medical Center – Shilpa B. Reddy, M.D.
  • University of Michigan – Erin Fedak Romanowski, D.O.
  • University of Arkansas – Debopam Samanta, M.D.
  • Children’s Health of Orange County – Daniel Shrey, M.D.
  • Atrium Health Levine Children’s Hospital – Rani Singh, M.D.
  • University of California San Francisco, Department of Neurology – Joseph Sullivan, M.D.
  • Ann and Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine – Priya Tatachar, M.D.
  • Mayo Clinic – Lily Wong-Kisiel, M.D.

Ongoing projects

Epilepsy Surgery Database – PrImary investigator: M. Scott Perry, M.D.

Past projects

Posters/Abstracts

Child Neurology Society Meeting 2019
Collaborating to Improve Epilepsy Surgical Care in Children: The Pediatric Epilepsy Research Consortium (PERC) Surgery Subgroup
View poster

American Epilepsy Society Meeting 2019
Characteristics of Patients Referred for Pediatric Epilepsy Surgery Evaluation in the US: Early Findings from the PERC (Pediatric Epilepsy Research Consortium) Epilepsy Surgery Subgroup
View poster

Time to referral for epilepsy surgery evaluation is longer in older children with intractable epilepsy – a potential opportunity for improvement.
View poster

American Epilepsy Society Meeting 2020
Factors Leading to >2 Antiseizure Medication Trials Prior to Epilepsy Surgery Referral in Children
View poster

Initial vs. Repeat Epilepsy Surgery Evaluation for Children in the US: Findings from the PERC (Pediatric Epilepsy Research Consortium) Epilepsy Surgery Subgroup
View poster

American Epilepsy Society 2021
Racial and Ethnic Disparities in Pediatric Epilepsy Surgery
View poster

Epilepsy Surgery in Tuberous Sclerosis Complex. Results from Pediatric Epilepsy Research Consortium (PERC) Epilepsy Surgery Database
View poster

Responsive Neurostimulation in Pediatric Refractory Epilepsy: Findings from the PERC (Pediatric Epilepsy Research Consortium) Epilepsy Surgery Subgroup – poster link pending

Comparing characteristics and outcome of palliative and definitive pediatric epilepsy surgery patients using the Pediatric Epilepsy Research Consortium (PERC) Surgery Database
View poster

Initial success and impact of building a collaborative among pediatric neuropsychologists
View poster

American Epilepsy Society 2022
A Multi-Institutional Comparison of Contemporary Surgical Approaches and Outcomes of Corpus Callosotomy – Coming in December 2022

The Impact of Presurgical Diagnostic Testing on Surgical Decision Making in Pediatric MRI-negative Drug-Resistant Epilepsy – Coming in December 2022
Stereoencephalography Planning for Phase 2 Monitoring and Risk for Hemorrhage – Coming in December 2022

Outcomes and Prognostic Factors of Pediatric Frontal Lobe Epilepsy Surgery: A Multi-center Study – Coming in December 2022

Papers
Surgical evaluation in children <3 years of age with drug‐resistant epilepsy: Patient characteristics, diagnostic utilization, and potential for treatment delays (wiley.com)

Special Issue: Seminars in Pediatric Neurology: Epilepsy Surgery Oct 2021
Seminars in Pediatric Neurology | Pediatric Epilepsy Surgery | ScienceDirect.com by Elsevier

Surgery Workgroup-Neuropsychology – MMB – Special Interest Group

We are a multi-site collaborative focused on maintaining a registry for epilepsy surgery outcomes. While seizures are a critical outcome, there is increasing recognition that outcomes beyond seizure control is critical to children and their families when evaluating the impact of epilepsy and its treatments. Cognitive and behavioral outcomes are the focus of the neuropsychology group. In addition, this collaborative not only advances science but also fosters growth and active collaboration within a network of pediatric epilepsy clinicians.

Members

  • Children’s National Hospital – Madison M. Berl, Leigh N. Sepeta, Hayley Loblein
  • Medical College of Wisconsin – Jennifer I. Koop
  • Boston Children’s Hospital – Alyssa Ailion, Katrina Boyer
  • Children’s Healthcare of Atlanta – Donald J. Bearden, Kim E. Ono
  • Cook Children’s Medical Center – Marsha Gabriel, Crystal M. Cooper
  • Atrium Health Levine Children’s Hospital – Amanda Max Decrow
  • Ann and Robert H. Lurie Children’s Hospital of Chicago – Frank Zelko, Priscilla H. Duong
  • University of Iowa Hospitals and Clinics – Patricia Espe-Pfeifer
  • University of Michigan – Elise Hodges, David F. Marshall, Brandon Almy
  • Nationwide Children’s Hospital – Kelly A. McNally
  • Vanderbilt University Medical Center – Andrew E. Molnar
  • Oregon Health and Science University – Emily K. Olsen
  • Seattle Children’s Hospital – Kristina E. Patrick
  • University of California -San Francisco – Brianna M. Paul
  • Children’s Health of Orange County – Jonathan Romain
  • Norton Neuroscience Institute – Rebecca LH Stilp
  • Children’s Colorado – Greta N. Wilkening
  • Mayo Clinic – Michael Zaccariello
  • Arkansas Children’s Hospital – Seth Sorensen

Funding

Funding for PERC Surgery Workgroup-Neuropsychology provided in part by the Pediatric Epilepsy Research Foundation (PI Berl) (http://pediatricepilepsyresearchfoundation.org/grants)

Current projects

  • Ongoing project: Online registry of pediatric epilepsy surgery and outcomes

Past projects

  • AES Dec 2021:
    Berl et al (2021). Initial Success and Impact of Building a Collaborative Among Pediatric Neuropsychologists
  • AES Dec 2022:
    Patrick et al (2022). Not all neuropsychological tests are created equal: Memory performance differences in patients with pediatric epilepsy
  • INS Feb 2023:
    Almy et al (submitted). The Importance of Executive Functioning for Academic Achievement Among a National Sample of Children with Epilepsy
  • Berl et al (submitted). Latent Wechsler Profiles in Presurgical Pediatric Epilepsy
  • Hodgest et al (submitted). Assessing Differences in Academic Achievement Among a National Sample of Children with Epilepsy Before and During the COVID-19 Pandemic
  • Moshe et al (submitted). Pediatric Frontal Lobe Epilepsy: Fine Motor Skills are Associated with Executive Dysfunction and ADHD Symptomatology

Member meetings

Virtual meetings are held ~every 2 months. A site is invited to join once a member of the PERC Surgery Workgroup; In-person meetings will be at annual meetings for either the American Epilepsy Society or International Neuropsychological Society

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